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Iterative Scopes closes on $30 million to advance its AI-driven precision medicine for GI disorders



Iterative Scopes, a pioneering company aiming to bring cutting-edge precision medicine to gastroenterology, today disclosed that it has closed a $30 million Series A financing. The round was led by new investor Obvious Ventures, with participation from Eli Lilly, Johnson & Johnson Innovation – JJDC Inc., the venture capital firms Breyer Capital and Seae Ventures, as well as a number of leaders in healthcare, including Lee Shapiro, Zach Weinberg and Nat Turner. The funds will be used to further develop the company’s core algorithmic innovations and to advance its growing life sciences businesses. This new round of financing follows a $13.5 million Seed round. Investors in the Seed round include Wavemaker Partners, Micron Ventures, Time BioVentures, Valor Capital Group, Tau Ventures, P5 Health Ventures, and Wavemaker 360.

Iterative Scopes was founded in 2017 as a spinout of the Massachusetts Institute of Technology (MIT) by Dr. Jonathan Ng, a physician-entrepreneur who developed the idea while at school at MIT and Harvard. The company is building a powerful set of proprietary artificial intelligence (AI)-driven computational tools to identify appropriate treatments and guide clinical trials for patients suffering from gastrointestinal diseases.

For a variety of reasons, gastroenterology has seen fewer benefits from precision medicine tools than other serious illnesses such as oncology and infectious diseases. Current endoscopic procedures are based largely on clinical intuition and produce highly subjective results, leading to wide variations in interpretation and delays in clinical trials.

“Our vision is to transform gastroenterology by augmenting the physician’s decision making through integration of computer vision algorithms into the everyday clinical workflow. These technologies also have the potential for biopharmaceutical companies to solve some of the most vexing challenges of GI clinical trials. We believe that the most successful healthcare technologies will be able to connect the dots between patient, provider, payer and pharma, and we are excited to be at the very forefront of this movement in gastroenterology,” said Jonathan Ng, CEO and founder of Iterative Scopes.

The initial products and services offered by Iterative Scopes aim to improve and standardize insights from endoscopic videos used for detection and monitoring of colorectal cancers and inflammatory bowel disease (IBD). Longer term, the company is building predictive models that can augment clinical trial endpoints and individualized therapeutic selection processes, with the potential to create novel endpoints that are better predictors of therapeutic response and disease outcomes. To do this, it is creating longitudinal patient datasets based on the aggregation of endoscopic data and genomic, molecular, and phenotypic information from electronic health records, registries and other sources.

Iterative Scopes’ technology platform has two initial applications. The first, a polyp detection algorithm, SKOUT, can assist clinicians in identifying hard to see polyps, enhancing the accuracy of their decisions. Through an exclusive AI-partnership with ProVation, the largest provider of GI endoscopy report writer (endowriter) services, the company is expanding its commercial reach into community and academic practices.

The second major near-term opportunity for Iterative Scopes is helping biopharma companies accelerate their clinical trials. Currently inclusion criteria for IBD clinical trials are largely based on disease severity scoring systems, such as the Mayo Endoscopic Score (MES). The same scoring systems also are used as primary or secondary endpoints in biopharmaceutical clinical trials for drug development. These metrics are highly subjective and dependent on physicians’ experience and intuition. Moreover, they present patient recruitment challenges and workflow inefficiencies. Iterative Scopes’ algorithms, among other benefits, enable physicians to use existing colonoscopy images to determine clinical trial eligibility. Furthermore, the company has developed technology that automates interpretation of colonoscopy videos and arrives at an MES score for individual patients. These solutions are helping clinical trial sponsors reduce costs, ensure better reproducibility of results, and overall improve their therapeutic positioning in an increasingly competitive field. In addition to taking an equity stake in Iterative Scopes, Eli Lilly has begun to use the company’s software for help with patient selection and assessment during clinical trials that are critical to the success of their products. Lotus Mallbris, M.D., Ph.D., Vice President of Immunology Development at Eli Lilly and Company, will also be joining the Iterative Scopes board of directors.

Mallbris notes, “Iterative Scopes has an interlocking portfolio of talented people, great ideas, solid results, promising alliances and an advisory board of outstanding experts. We are confident that we will be able to use what is being built here to improve efficiency of how we conduct clinical trials, which may allow much-needed medicines to get to our patients faster.”

As part of the financing, Nan Li, Managing Director at Obvious Ventures, will also join Iterative Scope’s board of directors. “The current standard of care in gastroenterology involves highly subjective patient diagnosis, stratification, and triage,” he noted. “Iterative Scopes has developed world-class AI capabilities to accelerate the industry towards drastically improved clinical decision-making and ultimately precision medicine. Obvious is thrilled to partner with this incredible company on their journey to realize this vision,” said Li.

About Iterative Scopes Iterative Scopes is fast becoming the leader in computational gastroenterology through its pioneering application of powerful, proprietary artificial intelligence tools to the practice of gastroenterology and drug development. It is taking a multi-tiered approach to tackling the challenges of endoscopic-driven disease management. The initial products and services offered by Iterative Scopes aim to identify and standardize relevant insights from endoscopic videos used for detection and monitoring of colorectal cancers and inflammatory bowel disease (IBD). Longer term, the company is building predictive models that can augment clinical trial endpoints and individualized therapeutic selection processes, with the potential to create novel endpoints that are better predictors of therapeutic response and disease outcomes. Spun out of MIT in 2017, the team is based in Cambridge, Massachusetts. For more information, visit www.iterativescopes.com.

About Obvious Ventures Obvious Ventures is a venture capital firm investing in entrepreneurs reimagining the global economy. Since launching in 2014, Obvious has backed over 70 companies using technology to create a smarter, healthier, more sustainable world. Obvious was co-founded by Ev Williams, James Joaquin, and Vishal Vasishth, with Andrew Beebe and Nan Li now also serving as Managing Directors. www.obvious.com